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• The ultimate role that natural preparations play will be complementary and might be useful in treating drug withdrawal and possibly relapse (Lu et al., 2009).
• Analysis was performed on every 5 minute sample after the commencement of drinking for 75 minutes, and on samples taken at 90, 120, 150, and 180 minutes.
• Seventeen men (21–33 years) who reported drinking 27.6 ± 6.5 drinks/week with a diagnosis of alcohol abuse/dependence took either kudzu extract (250 mg isoflavones, t.i.d.) or matched placebo on a daily basis.
• We found that, on average, each person consumed 7 units of alcohol after the placebo and, on average, 5.5 units after the kudzu.

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• The test requires individuals to press the space bar as quickly as possible following the appearance of a letter on a laptop computer screen, but to withhold pressing for any occurrence of the letter ‘X’.
• The impact of excessive alcohol consumption results in increased healthcare costs, loss of productivity, alcohol-related crime (including assault and sexual abuse), and motor vehicle accidents.
• In the second study, participants who were treated for 4 weeks with kudzu extract significantly reduced their alcohol consumption during weeks 2 through 4 of the study (Lukas et al., 2013).

However, it is interesting to note that two measures of physiological responses – heart rate and skin temperature – were accentuated by kudzu pretreatment. As these effects were seen only after the high alcohol dose, it would appear that this is evidence for a dose-response type of relationship. In addition, and perhaps of greater significance, is the possibility that ethanol levels rose more quickly at the higher dose of alcohol https://ecosoberhouse.com/ (0.7 g/kg) following kudzu pretreatment compared to placebo pretreatment. One interpretation of this finding is that kudzu extract does not potentiate the intoxicating effects of alcohol, but only hastens the onset of action in a dose-response fashion. In our previous study we demonstrated that the same kudzu extract used in the present study significantly reduced beer consumption in binge-drinkers (Lukas et al., 2005).

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Results from these experimental days again showed no effect of the kudzu extract alone on our measures. A standardized formulation of kudzu extract produced minimal side effects, was well-tolerated and resulted in a modest reduction in alcohol consumption in young non treatment-seeking heavy drinkers. Drinking was recorded using a custom built end table that contained a digital scale beneath a ceramic tile insert in the tabletop (Ohaus model #B10P with I5S controller). Participants were instructed to always keep the beer glass on the table except when taking a sip. The scale was connected to a computer in an adjacent room that ran a customized program that sampled the scale at 5 Hz and detected any weight changes that exceeded 1 gm.

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• Alcoholic drinks were made by mixing a name brand vodka (80 proof) with chilled orange juice.
• However, further research is necessary to fully comprehend the effects of kudzu on the body.
• Some health companies sell the kudzu root species Pueraria mirifica as a supplement for menopausal and postmenopausal women.
• I will discuss how it works, my experience with using powdered kudzu root for alcoholism, and recommendations.

The distal end of the catheter was passed through an opening in the chamber wall and attached to a 10-ml syringe mounted on a withdrawal syringe pump (Lukas et al. 1986). Syringes were changed every 5 minutes and the blood was put into Vacutainer® tubes containing K3EDTA (12 mg) as anticoagulant and placed on kudzu for alcohol cravings ice. The blood samples were then centrifuged and the plasma separated into a plastic vial. Quantitative analysis of ethanol levels was performed by gas chromatography with flame ionization detection (GC/FID) (Hewlett-Packard model 5890 series II equipped with a model 18593B autosampler) (Penetar et al., 2008).

In addition, participants reported pill taking by checking time-of-day boxes on daily diaries and by entries on the wrist actigraphy watches. Estimates of blood alcohol levels were obtained during each study visit using a breathalyzer device (AlcoSensor®, Intoximeter, St Louis, MO). They were required to come to the lab twice a week to provide urine, breath and blood samples to monitor drug use, alcohol drinking and liver function, respectively. A total of 227 breath samples were possible from all subject visits during the trial and compliance was equally distributed between the two groups; the kudzu extract group provided 131 of a possible 136 samples and the placebo group provided 84 of a possible 91 samples. Only one breath sample was positive for alcohol during all three phases of the study. A total of 21 adult males (17 Caucasian, 1 African American, 2 Hispanic, 1 Middle Eastern; mean age 23.8 ± 3.46 years, range 21–33) were recruited through advertisements in local and college newspapers and flyers posted in the Boston area.

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